课题内容
阿尔茨海默病的病理标志是老年斑，其中包含β-淀粉样蛋白纤维、小胶质细胞和星形细胞1。β-淀粉样蛋白纤维对神经元产生细胞毒性作用2，并刺激小胶质细胞产生神经毒素，如活性氧3,4。单核吞噬细胞，包括小胶质细胞，表达清道夫受体，介导氧化的低密度脂蛋白的内吞作用5，并粘附于葡萄糖修饰的细胞外基质蛋白6。在这里，我们报告A类清道夫受体介导啮齿动物小胶质细胞和人类单核细胞粘附到β-淀粉样蛋白纤维包裹的表面，导致分泌活性氧和细胞固定化。因此，A类清道夫受体是阿尔茨海默病的潜在治疗目标。
教授介绍
哥伦比亚大学
终身教授
1.2008年至2012年期间获得美国国防部专项资金。
2.2007年获得文理职业发展Revel奖。
课程大纲-美国和全球公共卫生疾病控制方法及政策研究
COURSE TOPIC: Foundations of Public Health
The Professor would like to tailorthe topic to the level ofthe students, so the syllabus can be
adjusted as needed. These details are subject to change at the professor’s discretion.
Course Description:
This interdisciplinary core course examines public health and healthcare in the US and globally using a social justice lens and emphasizing the interconnectedness of population and individual health. Using public health and healthcare delivery as the overarching framework, the course will cover foundational elements of public health, including, but not limited to, its history and impact, the importance of health equity and human rights, and how racism manifests and is perpetuated within public health and healthcare systems. The course will build a sense of community and instill a public health mindset among students learning and it will lay the foundation for students to work effectively as public health professionals on inter-professional teams.
Structure:
This course is broken up into four sessions, each spanning one week.
Schedule:
Session 1: Core Functions of Public Health
• Individual vs population health
• Ten essential services of public health
• Primary, secondary, tertiary prevention
• Introduction to determinants of health
• Social class, racism, discrimination and privilege in public health systems
Session 2: Healthcare Systems and Delivery in the US and Globally
• Approaches to healthcare
• Quality and coverage
• Implementation (e.g., cost, workforce)
• Regulatory systems
• Novel approaches to bridge healthcare and communities
• Social class, racism, discrimination and privilege in healthcare delivery
Session 3: Population Health: Past, Present and Future
• Trends in morbidity and mortality
• History of public health and impact of globalization
• Pragmatic challenges
• Diversity, equity, and inclusion
Session 4:Final
• Public health case:Take COVID-19 as an example
• Final project reveal
课程大纲-免疫系统原理机制及疾病抗体研究
COURSE TOPIC: Immunology and Vaccination
The Professor would like to tailor the topic to the level of the students, so the syllabus can be adjusted as needed. These details are subject to change at the professor’s discretion.
Course Description:
Immunology is a highly dynamic field that impacts topical and emerging issues within both the biomedical and biological science disciplines.
This course will see you learn about the components, principles and mechanisms of a healthy immune system, and how they co-ordinate to mount safe and appropriate protection against infection. You will establish how the immune system can distinguish between self and non-self targets, how it can tune responses to protect against different types of infectious agents and how responses vary when these agents are encountered in different anatomical sites, such as in the skin, gut and lung.
Structure:
This course is broken up into four sessions, each spanning one week.
Schedule:
Session 1 Introduction to immunology
Acquired immunity- characteristics
Antigen, Haptens and Adjuvants, Antibody
Types of immunity: nonspecificphysiological and cellular barriers
Session 2 Cells and Organs of Immune system
Organs of immune system – primary and secondary
Cells of immunsystem
Humoral Immuneresponse
Session 3 Immuno-techniques
Introduction to Antigen-antibody interactions
Affinity, avidity, cross reactivity, Precipitation reaction
Radial immune diffusion, Ouchterlony double diffusion
Function of vaccination
Session 4 Finals
Final Project Reveal
Vaccination and its development issues
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