一对一理科课题：了解Mac-1（CD11b/CD18）是一种寡核苷酸结合蛋白

课题内容

该教授研究了磷酸二酯和硫代磷酸酯寡核苷酸与Mac-1（CD11b/CD18；αMβ2）的相互作用，Mac-1是一种肝素结合的整合素，主要存在于多形核白细胞（PMNs）、巨噬细胞和自然杀伤细胞的表面。在αM和β2亚基上都发生了胸苷的均聚物的结合。可溶性纤维蛋白原是Mac-1的天然配体，是硫代磷酸酯寡核苷酸与TNF-α激活的和未激活的PMNs结合的优秀竞争者。

细胞表面Mac-1表达的上调增加了寡脱氧核苷酸的细胞表面结合。结合被抗Mac-1单克隆抗体所抑制，细胞表面结合的增加与PMNs内化的三至四倍增加相关。一种寡核苷酸抑制了β2依赖性通过Matrigel的迁移，但粘附在纤维蛋白原上的PMNs的活性氧的产生急剧增加。因此，我们的数据表明，Mac-1是寡脱氧核苷酸的细胞表面受体，可以介导其内化，这种结合可能有重要的功能后果。

教授介绍

哥伦比亚大学

终身教授

1.2008年至2012年期间获得美国国防部专项资金。

2.2007年获得文理职业发展Revel奖。

课程大纲-美国和全球公共卫生疾病控制方法及政策研究

COURSE TOPIC: Foundations of Public Health

The Professor would like to tailorthe topic to the level ofthe students, so the syllabus can be

adjusted as needed. These details are subject to change at the professor’s discretion.

Course Description:

This interdisciplinary core course examines public health and healthcare in the US and globally using a social justice lens and emphasizing the interconnectedness of population and individual health. Using public health and healthcare delivery as the overarching framework, the course will cover foundational elements of public health, including, but not limited to, its history and impact, the importance of health equity and human rights, and how racism manifests and is perpetuated within public health and healthcare systems. The course will build a sense of community and instill a public health mindset among students learning and it will lay the foundation for students to work effectively as public health professionals on inter-professional teams.

Structure:

This course is broken up into four sessions, each spanning one week.

Schedule:

Session 1: Core Functions of Public Health

• Individual vs population health

• Ten essential services of public health

• Primary, secondary, tertiary prevention

• Introduction to determinants of health

• Social class, racism, discrimination and privilege in public health systems

Session 2: Healthcare Systems and Delivery in the US and Globally

• Approaches to healthcare

• Quality and coverage

• Implementation (e.g., cost, workforce)

• Regulatory systems

• Novel approaches to bridge healthcare and communities

• Social class, racism, discrimination and privilege in healthcare delivery

Session 3: Population Health: Past, Present and Future

• Trends in morbidity and mortality

• History of public health and impact of globalization

• Pragmatic challenges

• Diversity, equity, and inclusion

Session 4:Final

• Public health case:Take COVID-19 as an example

• Final project reveal

课程大纲-免疫系统原理机制及疾病抗体研究

COURSE TOPIC: Immunology and Vaccination

The Professor would like to tailor the topic to the level of the students, so the syllabus can be adjusted as needed. These details are subject to change at the professor’s discretion.

Course Description:

Immunology is a highly dynamic field that impacts topical and emerging issues within both the biomedical and biological science disciplines.

This course will see you learn about the components, principles and mechanisms of a healthy immune system, and how they co-ordinate to mount safe and appropriate protection against infection. You will establish how the immune system can distinguish between self and non-self targets, how it can tune responses to protect against different types of infectious agents and how responses vary when these agents are encountered in different anatomical sites, such as in the skin, gut and lung.

Structure:

This course is broken up into four sessions, each spanning one week.

Schedule:

Session 1 Introduction to immunology

Acquired immunity- characteristics

Antigen, Haptens and Adjuvants, Antibody

Types of immunity: nonspecificphysiological and cellular barriers

Session 2 Cells and Organs of Immune system

Organs of immune system – primary and secondary

Cells of immunsystem

Humoral Immuneresponse

Session 3 Immuno-techniques